Web15 de ago. de 2024 · Hypoxia-inducible factor 1 (HIF-1) mediates the metabolic adaptation to hypoxia and ischemia, including the transition from oxidative to glycolytic metabolism. … WebHIF1 α decreased mitochondrial oxidation and promotes glycolysis metabolism in macrophages. (a and b) Metabolic respiratory parameters of peritoneal macrophages …
HIF-1-Independent Mechanisms Regulating Metabolic Adaptation …
Web3 de out. de 2016 · HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. … Web30 de out. de 2024 · Therefore, our work identified ACSL1 as a HIF-1-target gene that drives lipid metabolism. The results also suggest that the FABP5/HIF-1α axis can be used to … jesse cash ibanez guitar
Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to …
WebHIF-1 is a heterodimeric transcription factor complex, composed of two subunits: an O 2-responsive HIF-1α subunit, and a constitutively expressed HIF-1β subunit. The intact HIF-1 complex binds to hypoxia response elements (HREs) in the promoters of genes that govern diverse processes, such metabolism, proliferation, apoptosis, and angiogenesis. Web1 de set. de 2015 · 4.1.1. pVHL-dependent pathway. Under normal oxygen tension, HIF-1 α protein expression is negatively regulated by proteasomal degradation and ubiquitination in a pathway involving von Hippel−Lindau protein (pVHL), a tumor suppressor protein and one of the recognized components of an E3 ubiquitin protein ligase 27. Web16 de jun. de 2024 · HIF-1α silencing in fibroblast led to down-regulation of genes implicated in the metabolism of glycolysis and ultimately the inhibition of the glycolytic activity in these cells. Furthermore, we... jesse cedarbaum